LIN-42, the Caenorhabditis elegans PERIOD homolog, negatively regulates microRNA transcription.
During C.elegans development, microRNAs (miRNAs) function as molecular cashel tail bag switches that define temporal gene expression and cell lineage patterns in a dosage-dependent manner.It is critical, therefore, that the expression of miRNAs be tightly regulated so that target mRNA expression is properly controlled.The molecular mechanisms that